1、抗菌作用 2、抗真菌作用 3、抗病毒作用 4、抗阿米巴作用 5、抗炎、抗腹泻作用 6.、对心血管作用7、解热作用 8、降血糖作用 9、降血脂作用 10、抗氧化作用 11、对血液系统的影响 12、抗溃疡作用
《局方》三黄丸：治丈夫、妇人三焦积热。上焦有热攻冲眼目赤肿头项肿痛 口舌生疮；中焦有热心膈烦躁不美饮食；下焦有热小便赤涩大便秘结五脏俱热即生疽疖疮痍及五般痔疾粪门肿痛或下鲜血：黄连（去须、芦）、黄芩（去芦）、大黄（煨）各十两。上为细末炼蜜为丸 如梧桐子大。每服三十丸 用熟水吞》 如脏腑壅实加服丸数。小儿积热 亦宜服之。
《伤寒论》黄连汤：治伤寒，胸中有热，胃中有邪气，腹中痛欲呕吐者：黄连150克，甘草150克（炙），干姜150克，桂枝150克（去皮）人参100克，半夏250克（洗）大枣十二枚（擘）。上七味 以水一斗，煮取六升，去滓。温服 昼三夜二。
《本草经疏》：凡病人血少气虚，脾胃薄弱，血不足，以致惊悸不眠，而兼烦热躁渴，及产后不眠，血虚发热，泄泻腹痛，小儿 痘疮，阳虚作泄，行浆后泄泻，老人睁胃虚寒作泻，阴虚人天明溏泄，病名肾泄，真阴不足，内热烦躁诸证，法咸忌之，犯之使人危 殆。
黄连始载于《神农本草经》，列为上品。《本草纲目》中记载：“其根连珠而色黄，故名。”自古以来即认为四川为主产地，例如《名医别录》上说：“黄连生巫阳及蜀郡大山，二月八月采。”而巫阳及蜀郡均指四川。此外，本草记载在长江以东以及湖南、安徽诸省也产，如唐本草记载：“蜀道者粗大，味极浓苦，疗渴为最，江东（即今长江以东）者节如连珠，疗痢大著，今澄州（即今湖南澧县）者更胜。”再参阅重修政和经史证类备用本草中“澧州黄连”和“宣州（即今安徽宣城）黄连”以及《植物名实图考》中的黄连附图，特别是后二者可以清晰地鉴定即系黄连属(Coptis)植物无疑。因而可以认为我国自古以来即以四川一带的黄连 C. chinensis 及长江流域下游一带的短萼黄连 C. chinensis var. brevisepala 同时一并药用。
Coptis (Ranunculaceae) Edit
This entry may involve expertise is not no toxic side effects of Chinese herbal medicine, prescribed medication, please, do not believe drugs online recommendations.
Berberine, (scientific name: Coptis chinensis Franch.) Alias: taste even, Kawatsure, even chicken feet, is a Ranunculaceae, berberine is a perennial herb, leaf base helpless, Kennedy papery, ovate-triangular, three full-lobed, central lobe ovate diamond, pinnatipartite, sharp serrated edge, lateral lobes unequal 2 parted; petiole length 5-12cm. Wild or cultivated valley at an altitude of 1000-1900m cool wet shaded jungle. There is heat and dampness, purging fire detoxification. Its entrance very bitter taste, there is the saying goes, "哑巴吃黄连, suffering not to say," that revealed the taste.
Chinese scientific name berberine Latin name Coptis chinensis Franch. Nickname taste even, Kawatsure, chicken and even two law Coptis chinensis community Flora door Angiosperms Gang Dicotyledon subclass original metachlamydeae outline Ranunculales Ranunculus Keya Ke Branch Thalictrum subfamily ethnic belonging of berberine berberine berberine species distribution area in southern Sichuan, Guizhou, Hunan, Hubei, Shaanxi
Contents 1 Morphology 2 3 geographical distribution of growth habit 4 5 cultivation techniques breeding methods ▪ Cultivation management ▪ pest control ▪ Field 6 7 Identification of the medicinal value of the chemical composition 8 9 10 plants and cultural history
Morphological characteristics editor
Yellow rhizome, often branching, most dense fibrous roots. Ye have long handle; blade slightly leathery, ovate-triangular, 10 cm wide, three-wide crack, the whole central lobe rhombic ovate, 3-8 cm long, 2-4 cm wide, apex acute, long 0.8 -1.8 cm shank, 3 or 5 pairs pinnatipartite in the division below the deepest, deep lobes 2-6 mm from each other, with raw edges sharp thorns finely serrated, lateral lobes with full length 1.5-5 mm handle, obliquely ovate, lobes shorter than the central whole, ranging from two-parted, the veins bulge on both sides, in addition to the outer surface along the veins are pubescent, and the rest glabrous; petiole 5-12 cm long, hairless.
Scapes 1-2, 12-25 cm high; dichotomous or dichasium 3-8 flowers; bracts lanceolate, three or five pinnatipartite; sepals yellow-green, oblong-shaped egg shape, length 9-12.5 mm, 2-3 mm wide; petals linear or linear-lanceolate, 5-6.5 mm long, apex acuminate, the central groove honey; stamens about 20, anthers ca. 1 mm, filament length 2-5 mm; carpels 8-12, style slightly curved outside.
Follicles 6-8 mm long, with handles approximately equal length; seeds 7-8 tablets, oblong, ca. 2 mm, a width of 0.8 mm, brown. February to March flowering, from April to June results. 
China Plant Image Library (Institute of Botany) provide and co-edited
Berberine whole plant
Berberine whole plant (2)
Berberine foliage (1)
Berberine fruit (1)
Growth habit editor
Huanglian Xi cold, wet, shade, avoid high temperature, drought. General distribution in the high mountains of 1200 ~ 1800m, require low temperature, air humidity of the natural environment. We can not withstand strong sunlight, like low light, and therefore need shade.
Shallow roots, distributed in the soil 5 ~ 10cm, suitably loose and fertile topsoil, humus rich, deep soil, pH5.5 ~ 6.5, is acidic. Under Health elevation alpine alpine tree-lined between 1500 to 2300 m, sometimes wild or cultivated.
Geographical Distribution Edit
Distributed in Sichuan, Guizhou, Hunan, Hubei, southern Shaanxi. Health and altitude between 500-2000 meters mountain forest or valley shade, wild or cultivated. The type specimen was collected from the port city of Sichuan. 
Reproduction Method Editor
Berberine pictures (21)
Propagation by seed. After the end of the embryo cooked seed type. In early May the seeds after harvesting, choose a cool hillside relatively flat ride with tree branches shade, rain Drizzle naturally shed, 20cm deep to dig pits for the seeds with wet sand in the cellar stratification storage. Sooner or later, and after the fall of temperature,
Gradually formed embryo development. 10 to 11 months after the gap between seed sowing in Takakuro, every child 1hm2 sown 22.5 ~ 37.5kg, covered with cow manure. In late February the following year to take short Qimian shed shade emergence early in March, to pick Qimian leaves and weeds in addition to the net. Seedlings should be between 5 to 6 months reminder seedlings topdressing fertilizer quick result, between 10 to 11 months sprinkle finely cow manure and ashes humus to benefit the winter.
Even the traditional planting techniques are used scaffolding shade, in winter, cutting down trees to take shade 1.2m high, about 70 percent shade degree, shed for 1.6m wide Takakuro (car). The first three years after planting between March seedling nursery has grown from 4 to 6 true leaves, transplant, row spacing 10cm × 10cm, planted deep 3 ~ 5cm, 75 ~ 90 万株 per 1hm2 Zaimiao. Useful intercropping between corn and forest planting technique even in winter in Qimian row spacing 1.6m square, spaced planting hemp, mulberry bushes and pine, fir and other trees. Early spring in late February for nutritional bowl seedling cultivation of corn in a plastic dwarf shed.
When the height of about 30cm in height on both sides to furrow spacing 30cm, the leaves of maize seedling transplanting leaf orientation, 6, July corn leaves after sealing ridge between rows planted berberine. After the winter maize harvest, corn stalks woven short shelf for berberine shade. The following year re-planted corn, about 4 to 5 years after the bush has become a forest, for berberine shade, no longer planted corn.
Berberine in the forest after harvesting the land, enough base fertilizer, can be planted even then; shrubbery planted Coptis 2-3 postseason, has become a forest of trees, shrubs can be cut, even tilted downward and crashed in forest trees. Planting shade technique using corn and even planted, not only does not affect berberine yield, labor, and material, save and invest, live trees are not planted berberine savings than twice as fast in the woods. 
Cultivation Technical Editor
Berberine - medicinal parts
Berberine - medicinal parts
Select the soil deep, loose and fertile, humus-rich, draining power, permeability can be good oil bamboo weed, the soil is slightly acidic to neutral, the terrain in order to sooner or later have oblique light irradiation does not exceed 30 degrees gentle slope appropriate. Avoid continuous cropping.
Growing demand berberine selection, seeding, transplanting process. Usually 2 years after seedling transplanting, spring, summer, autumn can be transplanted three years ago after transplanting, should promptly fill the gaps, weeding. Transplanting 3 to 4 years of berberine, weeding 3 or 4 times per year. From the second year, in addition to stay outside planting plants, flowers moss should be promptly removed. Planting cultivation process, according to the age and growth of plants planted requirements, adjust the degree of shade of Yu shield.
Berberine - medicinal parts
Berberine - medicinal parts
There can be planted every year three times: the first time in 2 to 3 months after snow, before berberine not grow new leaves, high survival rate after transplanting, shortly after transplanting hair new leaves, grows new roots grow well into the V After Simiao less is even better planting time, the people known as "old plant leaf." The second period is in May and June, when the new leaves have grown into large seedlings, transplanting survival rate is high, growth is also good, the people known as "Deng planted seedlings." But not later than July, due to high temperatures in July, after transplanting Simiao more serious off nest, growth is also poor. The third period in September and October, soon after transplanting into the frosty, rooted fledgling, on the case of winter frost, frozen vulnerable pull seedlings, the survival rate is low, at low warm ice-free area, was planted at this time.
Stout extractor before planting seedlings from seedbed. When pulling seedlings with his right index finger and thumb and pinch small seedling roots uprooted, shaking off the soil, into the left hand, thumb on one side of rhizomes, seedling first place tidy, fibrous roots straightened out, can not bend, 100 bundled into one the. When pulling seedlings fibrous roots have been damaged, lost vitality, to be reborn after transplanting new roots before planting it at a distance of 1 cm at head, cut long fibrous roots. If the "through-bar method" transplanting, fibrous roots should stay longer, about 1.2 to 2 cm. After cutting fibrous roots, soil water to the roots of seedlings washing clean, when planted easy to operate, easy to induce new rhizome root contact with the soil, while the seedlings to absorb moisture, when freshly planted seedlings, transplanting easy to survive. Usually pull Sicko morning, afternoon, planting, planting the best finish that day; if not planted finished, should lay it in wet places, still soaked in water before planting the next planting. With ammonium molybdate aqueous solution of 1 to 2:500 kg root dipping 2 hours, can promote seedling root, accelerate growing; 1:500 0.5 kg of potassium permanganate solution Baptist roots two hours, there are hair roots and accelerate growth effect.
Seedlings should be planted in a sunny or cloudy day, it can not be carried out in the rain, because rain will tramping Qimian paste the seedlings on the mud, not easy to survive. Planting methods are three kinds: one is planted back knife, utensils dedicated small heart-shaped wooden handle shovel. When planted right hand shovel, and a left hand to take a seedling from the right hand with a large, food, middle finger and take the seedlings, with a large, food, middle finger hold the upper part of seedling, then the shovel vertically into the soil, depth of 4 ~ 6 cm, flat chest to pull 2 to 3 cm, to make into a vesicle, the seedlings correct insertion hole, and immediately remove the small shovel, dozer good Xuekou forward cover, pressing with back of shovel seedlings. From top to bottom, side planted side back, and subsequently stretch to loosen the soil, flatten footprints. Zaimiao should not be too shallow, generally less blade-age seedlings should be completely buried, most no more than 6 cm square easy to survive, usually 10 cm row spacing, planting square, can be planted per acre 5.5 to 60,000. Second, planted the sword, that with a shovel seedling pressed fibrous line buried. This hydroponic plant faster, but the survival rate is less than planted back knife high, generally less use. The third is planted through the rod in one hand and planted seedlings when the other hand index finger pressed against the roots, into the soil, the index finger a little rotation, out of fingers, then bulldozing cover finger hole. This method Zaimiao faster, the survival rate is high.
Berberine after planting, a small amount of cow manure applicator immediately and said knife smoked soil fertilizer. Each year in early spring, after the summer and winter seed harvest between 10 to 11 months and each dressing 1, the spring and summer to nitrogen and phosphorus-based fertilizers and other quick result, winter fat cattle manure and smoked soil, should be applied after each earth fertilizer. Article 1, Section 2 of earth about 1cm, 3rd, 4th year 2 ~ 3cm. 
Before dressing should be weeding, 2012 after transplanting small seedlings exposed to large pores, prone to weeds, weeding each year should be 4 to 5 times, four or five students berberine has sealing ridge, combined with weeding fertilizer three times a year. Scaffolding planted even after seed harvest in May that year should be thrown open sun canopy cover, inhibit the growth of leaves, roots prompted substantial; forest planting company, beginning the third year after transplanting winter pruning should shed light, so Shadings about 70% by the plant even when reduced to 20% to 30%. 
Fill the gaps with seedlings
After planting different degrees of Simiao often nest removal, transplanting the first two or three years, about 10% of the seedlings die each year, should be timely fill the gaps, generally Bumiao twice, the first time in the autumn of the year, with seedling age were Bumiao, with soil easier to survive transplanting. Second Bumiao not made before the new leaves after the second year of snow. In winter, the frozen alpine region larger, often head seedlings planted in autumn arch out of the ground, so when the snow detail view, the arch out of the ground the seedlings by hand in the human soil, still survived. Planting monthly seedlings should be found dead. Thereafter if found Deficiency, should be used with considerable Zaimiao transplanting seedlings with soil so that consistent growth after transplanting.
Due to take a pre-emergence herbicide, it should be combined with chemical weed control in the planting year and next year, weeding 4-5 times per year, and the third, three to four times a year for four years, the first five times, each time in the grass 2 to 3 leaves, with prometryne 250 grams, simazine 25 to 30 grams, rice once net (Yongchuan production) 2 packs (three drugs when administered with only one of them), and 20 ~ 30 one thousand Kashagan or fertilizer mixed in the sunny afternoon or evening, and cloudy evenly applicator in acres of soil berberine (counting only the net surface area of the car), with bamboo sticks or branches fall to the sweep. Then, careful observation, if there is no net addition to weeds, manual removal.
2 to 3 days after transplanting should be applied once dressing with thin shavings of water or water pig manure can also be finely divided compost or manure per acre with about 1000 kg withdraw facilities. The fertilizer called "knife-edge fat", can survive even after the seedlings grow rapidly. Planted in September and October that year, the second, third, four or five years in the spring May seed and the second, third, four autumn 9 to 10 months, should the facilities dressing 1, a total of eight times. Ren Chufen spring fertilizer per acre with 1000 kg of water and 20 to 30 kg superphosphate, and fine soil or fine compost mix applicator, after applying to the thin bamboo leaves attached Saola fertilizer. Fall forced to farm manure-based fertilizer, used along with ashes, cakes and other fertilizers; fertilizer should get fine full maturity, withdrawal Shi Qimian, 1 cm thick, the amount per acre from 1500 to 2000 kg; if fertilizer is insufficient, the available humus instead of part of the earth or farmyard manure. Fertilization should be increased year by year. Dry fertilizer applicator when applying upward from the lower to avoid piles of manure or cover leaf rolling, vulnerable to rain erosion at the slope of the upper and side plot, poor fertility, should be applied several.
Berberine roots grow upward, forming a internode per year, in order to increase production, the second, third, four years after the fall of dressing should be earth, humus soil collected in the vicinity of the plot to get a fine retreat. Second, three years sprinkle about 1 cm thick, known as the "flower mud"; the fourth year of the withdrawal of about 1.5 cm thick, known as the "full of mud." Earth shall be uniform and not too thick, otherwise the roots stems long bridge, lower the quality.
On the basis of the dressing on the mud, even the majority of farmers in order to increase production, still every chemical fertilizers promote its growth after the weeding. By comparison test, administered 50 kg superphosphate per acre and 10 kg of ammonium bicarbonate is the best ratio.
The main diseases are powdery mildew, should be reduced to increase the degree of light and shade available lime sulfur control. Pests are grubs, mole crickets, etc., can bait trap. There Jizi early spring, golden pheasant damage moss and flower seeds, should be enclosed by a fence, strengthen artificial hunting, more harm reduction. 
Medicinal value edit
Heat dampness, purging fire detoxification. For hot and humid fullness, vomiting Tunsuan, dysentery, jaundice, fever, coma, Firelight hyperactivity, upset insomnia, blood heat spit bleed at the nose, red eyes, pain, diabetes, carbuncles boils; external treatment of eczema, eczema, ear pus. Qing Huang Lianshan wine on hot coke. For red eyes, mouth sores. Ginger berberine stomach vomiting and stomach. Each node for cold and heat, damp heat resistance, fullness and vomiting. Dogwood berberine Shugan vomiting and stomach. For liver and stomach, vomiting Tunsuan. 
1, 2 antibacterial, antifungal effect 3, 4 anti-viral, anti-amoeba effect 5, anti-inflammatory, anti-diarrhea effect 6, 7, 8 antipyretic effect on cardiovascular effect, hypoglycemic effect 9, fat the role of 10, 11 antioxidant effects on the blood system 12, anti-ulcer effect 
For the crowd
Oue empty stomach, spleen diarrhea, kidney just before dawn diarrhea who were careful service.
This product is great bitterness Big Chill, over service Jiufu easily hurt the stomach, spleen and stomach were hanged. Bitter dry disability allowance, Yin-chun injured caution.
"Bureau" three yellow pill: governance husband, woman triple burner heat accumulation. Focus on the red eyes red hot tapping items swollen head swollen mouth sores; coke enthusiastic diaphragm irritability US diet; under the coke heat constipation, urinary astringent internal organs all heat that is born gangrene boils wound like hemorrhoids and five Dung Gate swelling or lower blood: berberine (to the subject, Lo), skullcap (go Lo), rhubarb (simmer) for each twelve. For the fine refining honey for the pill, such as the Indus sub-major. Each serving thirty pills with boiled water swallow "such as solid organs obstruct pills plus service number. Pediatric service of heat accumulation should be matched.
"Treatise on the" Coptis soup: cure typhoid fever, chest hot, there is evil in the stomach, belly pain, vomiting desire: berberine 150 grams, 150 grams of licorice (Sunburn), ginger 150 grams, 150 grams Guizhi (peeled) 100 grams of ginseng, Pinellia 250 grams (wash) jujube twelve (break). On Qiwei a bucket of water, Zhuqu six liters, to sediment. Warm clothes day and three nights II.
"At the party," Huang Lianan Shishenwan: governance according to repeatedly upset Oh, fretting, Zheng Zhong, the hot gas chaos chest. Xin Xiapi stuffy. Ingestion Anti-out: cinnabar 20 grams, berberine 25 grams of raw licorice 12.5 g. Fine, Soup, Zhengbing Wanru millet big. Each serving food after a nineteen-chun always swallow saliva.
"Council" Xiexintang: excess heat treatment Heart Sutra: berberine 35 grams. Water a half a fried food away warm clothes Save the children.
"Annotations of Materia Medica": evil chrysanthemum, Wuhu flower, Scrophulariaceae, fresh white; fear coltsfoot.
"Shu Materia Medica": fear bidentata.
"Outline": berberine bitter Big Chill, dampness with the pathogenic fire, the disease that, when the stop, how can long take, so chill of the Standing Order, while cutting its gas germinal impulse and peace?
"Materia Medica is": Huang Lianshan diarrhea Heart and real fire and Hot abused, will come to Georgia yang, so Zong Ying Kou Day: virtual and cold person, Shen Wu light use; Wang possession date: summer month long bloody diarrhea without berberine, including Yin also ʱ??
"Ben Cao Jing Shu": Where the patient less blood deficiency, weak stomach, lack of blood, so that fright, insomnia, and Fanre impatient and thirsty, and postpartum insomnia, anemia, fever, diarrhea, abdominal pain, pediatric smallpox, Yang for leaks, line after pulp diarrhea, stomach Deficiency wide open for the elderly diarrhea, Yin people dawn pond vent, vent kidney disease name, really yin deficiency, heat irritability all evidence, law salty bogey, invading people in critical condition.
"Shen Nong's Herbal Classic": bitter, cold. Indications heat, eye pain, canthus injury, weeping out of eyesight, intestinal bleach, abdominal pain, diarrhea, woman Yin throat. Jiufu forget.
"Doctors do not record": slightly cold, non-toxic. Indications Wu Zang cold, long discharged bleach, sepsis, only diabetes, shocked, in addition to water, Lee bone, Tiaowei, thick intestine, bile benefit, cure mouth sores.
"Herbal Supplements": Main Leishou shortness of breath.
"Medicinal theory": evil white silkworm, avoid pork, bad cold. Malnutrition in children kill insects, point faint red eye pain, liver town, go hot poison.
"Japan Hanako Materia Medica": governance debility, Qi, stop heart pain, palpitation, irritability, Run cardiopulmonary, flesh, bleeding and sores, night sweats, hot illness day trip. Pork bellies steamed for the pill, cure infantile malnutrition gas.
"Kai Bao Materia Medica": bitter, slightly cold, non-toxic. Five internal organs hot and cold, long discharged bleach, sepsis, only diabetes, shocked, in addition to water conservancy bone, Tiaowei, thick intestine, bile benefits, treatment and mouth sores.
"The sketches by": Coptis governance objectives party more, and goat liver pills Youqi different. Cover the eyes of the disease, all the blood stagnate dictates, so as to xue medicine Huanglian rule. Blood is too hot line, it can also take the hot wash.
"Ben Cao Yan Yi": more people today with the anti-malaria, cover of execution to justice bitter dry. Vulgar under virtual leaked to the whole intestinal micro seems bloody stool, ready to use it, but I do not know stop. And regardless of how much cold and heat, but to make the agent for the degree, the cause is more doom and gloom. If the gas real early disease, heat more bloody diarrhea, they stop serving it, still do not have to make the agent also. Or empty and cold, not to be served. I like "warp."
"Act like a drug class": diarrhea Firelight, in addition to stomach the heat, cure irritability, nausea, swelter in the coke, Wu Wu Yu Tu. Fullness will not cure heart medication also. Zhongjing rule nine kinds Xin Xiapi, five and so Xiexintang all use it.
"Medicinal Fu": bitter, flat, cold air, non-toxic. Shen also, yin. Its use has four: Full of like diarrhea Firelight, elimination Xin Xiapi; primary intestinal bleach, in addition to the mix of red intestines; cure eye disease outbreak is appropriate, treatment with sore all inclusive.
"Herbal Decoction": air cold, bitter. Wei Hou thin air, Yin Zhongyang also. L also non-toxic.
"Like" Cloud: diarrhea Firelight, in addition to stomach the heat, cure irritability, nausea, swelter in the coke, Wu Wu Yu Tu, Xin Xiapi full medication will also. Zhongjing rule nine kinds Xin Xiapi, five and so Xiexintang all use it. To have to use.
"Heart" goes: Xiexin by fire, storm swollen red eye sore Jizhu shall use it. Bitter cold were the main positive surplus, bitter to remove it. An roundworm, through cold cells, treatment under the coke true, strong kidney.
"Jane" goes: Jiuchao up, Jiujin top row.
"Materia Medica" Cloud: Main heat, head pain canthus injury weeping out of eyesight. Abdominal pain, diarrhea, intestinal bleach, woman Yin throat. Five internal organs hot and cold, long pus discharged bleach, only diabetes was shocked, in addition to water conservancy bone, Tiaowei thick intestine, bile benefits, treatment and mouth sores. Jiufu forget.
"Solution" goes: start Shao, bitter dry, so into the heart, the fire was too dry. However Xiexin fact spleen also, for the child make a real mother, actually spilled his son. Windbreak for the treatment of blood on the make, berberine is manipulation, Burnet for the next make.
Tibetan ancestral sea side, so life is not made sore spot: when fried berberine bite, children born not out loud, filling the big should. She has been filling it out loud, although spot hair, but also light. Cuban side to berberine most anti-malaria.
"Yan Yi" Cloud: anti-malaria micro blood, unenforceable berberine. Desiccant is bitter, empty were more doom and gloom caused, it is appropriate to the real person.
"Herbal" Yun: keel, marble, skullcap whom make, evil chrysanthemum, Daphne, Scrophulariaceae, fresh white skin, fear Coltsfoot wins aconite, Croton toxic solution.
"Ben Cao Yan Yi Addendum": fried with ginger Xinsan, heat removal active.
"Herbal play": a chat camera goes: into the heart of bitter, cold heat removal. Rhubarb, berberine bitter to the heart under Hot catharsis. Yun: vent the heat by bitter, bitter Coptis dynasties yang. Yun: roundworm is moving too willing to give pain is safe, berberine, Treats pain to security roundworm.
Jie Gu Yun: diarrhea Firelight, in addition to stomach the heat, cure irritability, nausea, swelter in the coke, Wu Wu Yu Tu. Bitter, smell all thick, may go up or down, Yin Zhongyang also. Its use has five: Xiexin hot one too, to the coke fire two also, such sores will also use three, four also went to rheumatism, five outbreaks of red eye also. Jiuchao the upside. Yun: go coke wet and hot, with berberine diarrhea Firelight it is also. Eye pain can not ninja, with berberine, angelica root, Jiujin decoction. Sushi Needless who, with berberine, citrus aurantium.
"Compendium of Materia Medica": berberine bitter Big Chill, dampness with the pathogenic fire, the disease that is when the stopper.
"Ben Cao Jing Shu": intrinsic world berberine raw cold gas to generate, so the smell of bitter cold and non-toxic. Wei Hou in air, bitter and thick yin. Should it discharged, purports to be added upstream guide. Starting Shao, Yangming, foot Shaoyang, Jue Yin, foot Yangming, lunar. Xianyao disease as wine, god grass under stagnation. Six by actions, each Shugong. Its main heat, head pain hurt canthus tears out, eyesight, who shocked the benefits guts, cold heart and gallbladder are clear. Abdominal pain, diarrhea and intestinal bleach.
"Do not record" and the main vent bleach. Who vent, diarrhea Lee also; bleach who is also the large intestine of blood, commonly known as dirty drug. In addition to water conservancy bone, thick stomach, cure mouth sores who eliminate intestine, stomach, spleen three of the hot and humid also. Jiufu not forget who is the heart of home fire no clear, clear the next, so forget it.
"Ben Cao Meng Quan": bitter, cold air. Wei Hou thin air, can go up or down. Shen also, yin, yin yang micro. Non-toxic. Fire cure all evil, according to each system fry.
"Herbal Take Ya": Ling bitter cold of winter, the cold water; the yellow section, Turkey's system, also sentenced to heart medication. Hot on inflammation, inflammation of the work that is suffering the goods, with the differences, the varying changes of the resistance, so that peace.
"Herbal solution": berberine, bitter, cold, non-toxic, into the heart. Main heart flame, eye disease outbreak, sore swelling, bowel red diarrhea, fullness, diarrhea, infantile malnutrition heat elimination in mouth sores, palpitation, irritability, Sky heat illness.
"Materia Medica truth": Great diarrhea Firelight excess heat.
"I was equipped with Materia Medica": skullcap, Long muscle, marble whom make. Fear Achyranthes, coltsfoot, bad cold, chrysanthemum, Scrophulariaceae, white silkworm, fresh white skin, Daphne. Avoid pork. Kill aconite, Croton, light pink poison.
"Ben Cao Jing solution": Coptis cold air, cold winter days, the water vapor Bing, into the kidney meridian; bitter, non-toxic, have fire flavor to the South, starting Shao Yin Heart Sutra. Smell all down, yin. Its main hot head pain also, Heart fire, fiery hot, heart disease Scotia liver, liver opens into the eyes also, berberine bitter cold, so clear the fire. Shao positive pulse hand, for face, within close canthus, hand Shao as Firelight, H.-S., the anxious heart and tears out; canthus wounded, all Firelight, berberine heart, so Lord. Actually spilled his son, heart, wood is also the son, a pure heart is liver Xie Xie, so eyesight also.
"Shen Nong's Herbal Classic Reading": Coptis cold air, cold winter days, the water vapor Bing, into the kidney meridian; bitter, non-toxic, have fire flavor to the South, starting Shao Yin Heart Sutra, gas and water and flavored water, a with all things, it can remove water and fire chaos, and the heat of the disease.
"Shennong one hundred kinds of record": taste bitter. Primary heat, heat removal in the gas separation by. Eye pain, tears out canthus injury, eyesight, in addition to the disease on the hot and humid. Abdominal pain, diarrhea, intestinal bleach, in addition to hot and humid.
"Sutra card": Coptis Roots Cong Yan, Man cited with the case, a total of one hundred stems several who even named its governance resembles flooded long delay of the card, such as prostitution sore berberine powder is Lord of men, husband name steeped, the non-violence was the beginning of the disease, nor a cure can heal the candidate, so the Golden Chamber Treatise on two books, never get sick with berberine by the new.
"New Materia Medica": berberine, bitter, cold, may go up or down, Yin is also non-toxic. Into the heart and cellular network. Most purging fire, also the liver. About the same cited by the drug, all to get into it, into the room the heart, especially designed by the well. Lee Tunsuan antiemetic, benevolent thirsty. Governance FireCam even God, can feel at ease, only nocturnal emissions, will be manic, except fullness, to the woman as swollen vulva. Treatment of Infantile rickets soil for food, hot weather heat, heat, swelter, there is a special function.
"Herbal divided by": big bitter Big Chill. Into the heart and purging fire, Zhengan cooling, dampness Gloomy, can eliminate minded bad blood, but also diarrhea spleen fire. Jiuchao rule on the coke fire, ginger fried governance in the coke fire, the next water treatment fried coke fire.
Therapeutic amount of berberine quite safe, side effects are rarely, long-term use is also no any obstacles, or used in conjunction with an oral berberine berberine 2.0g 100g powder did not show any side effects. In animal studies, toxicity is also very light, easy oral lethal to mice, the minimum lethal dose intraperitoneal injection of 0.01g / kg, also measured obtaining the median lethal dose of 0.066g / kg (cork or berberine were each 0.52 , 0.73g / kg).
Cat oral 0.1g / kg can cause systemic suppression, vomiting, at 8 to 10 days after the death, the excitement turned to breathing paralysis, seizures can occur before death. Berberine sulfate mice by intraperitoneal injection of lethal dose of 24.3 mg / kg. Tetrahydroberberine fed to mice, subcutaneous and intravenous median lethal dose was 940mg / kg, 790mg / kg and 100mg / kg.
Berberine hydrochloride in mice by intraperitoneal injection of lethal dose of 24.3mg / kg. The most serious toxic berberine cardiac toxicity, in clinically acute cardiogenic cerebral hypoxia syndrome, 100mg infusion in glucose solution, patients have dizziness, shortness of breath, heart rhythm disorders, circulatory and respiratory arrest absorption, etc. and deaths have been reported. Allergies are more common, berberine injection (0.1%) 2 ~ 4ml, there are systemic itching, hives, fever, palpitation, joint pain, breathing Di promoting, irritability, nausea, vomiting, severe can decrease in blood pressure caused by anaphylactic shock. 
Rhizome multi tufted branches, bent giant hug, pour chicken-like shape, commonly known as chicken berberine; single branch class cylindrical, long 3 ~ 6cm, diameter 2 ~ 8mm. Surface greyish yellow or yellow-brown, the skin peeled position was reddish brown, rough, irregular nodular uplift, fibrous roots and fibrous residue, among some sections smooth surface such as stems, Xi said the bridge; the upper multiresidue brown scales Ye, the top often leaving residual stem or petiole. Quality hard, irregular fracture surface, sheath or dark brown orange red, Kibe bright yellow or orange, pith red-brown, sometimes hollow. Gas micro, taste very bitter. 
Scale leaf tissue often fall off. Cork layer of cork cells several columns. Cortex wide, some visible traces roots and leaf trace vascular bundles; yellow stone cells, a single or a few scattered groups. Paper bundle outside the tough type, arranged in a ring intermittently, between the beam-forming layer is not obvious. Outer phloem fiber bundles, ranging in size to several tens or hundreds of fiber; some accompanied by yellow stone cells. Xylem yellow, all-wood; wood fiber is developed. Room pith parenchyma cells sometimes visible minority groups exist in single or stone cells. Parenchyma cells inclusive of starch grains. 
Yellow-brown or yellow.
① stone cells bright yellow, round, class square, polygonal or slightly extended, diameter 25 ~ 64μm, about to 102μm, wall thickness 9 ~ 28μm, pits obvious, some laminated obvious.
② many wood fiber, yellow, slender; diameter 10 ~ 13ctn, thicker wall, wood-based, pits sparse.
③ bast fibers bright yellow, spindle or fusiform, long 136 ~ 185μm, diameter 25 ~ 40μm, wall thicker than the thin pit.
④ catheter Lord pitted and thread pipe diameter 8 ~ 20μm.
⑤ starch grains more than a single grain, oblong, kidney-shaped, spherical or oval, diameter 1 ~ 10μm; complex particles minority from 2 to 4 points grain composition. Scale leaf epidermal cells greenish yellow or yellow-brown, slightly rectangular, curved walls of the microwave. 
Physical and chemical identification
(1) This product fracture surface under ultraviolet light was yellow fluorescence, xylem is particularly significant. 
(2) take the powder about 1g, plus ethanol 10ml, heated to boiling, let cool, filtered, the filtrate 5 drops of dilute hydrochloric acid 1ml with a small amount of bleach, which was cherry red; another 5 drops of the filtrate, add 5 ethanol% gallic acid 2 to 3 drops, evaporated, add a few hot drops of sulfuric acid, which was dark green. (Check berberine) 
(3) take the powder or slices, add dilute hydrochloric acid or nitric acid 1 drop of 30%, after a moment microscopy, visible yellow needles cluster, heating crystallization was red and disappear. (Check berberine)
(4) take the powder TLC approximately 1g, add methanol 10ml, heated to boiling, let cool, filtered, and the filtrate as the sample solution. Another berberine hydrochloride palm leaf Tet, hydrochloric acid and hydrochloric acid jatrorrhizine Magnolia base as reference substance, add methanol 1ml each containing 2mg of the mixture as a control solution. Silica gel thin layer at the point of sample solution plate 1 ~ 2μm, control solution 5μl, chloroform - methanol - aqueous ammonia (15: 4: 1) to expand, remove, dry. The resulting chromatogram, in natural light and palmatine berberine has alkali show yellow, jatrorrhizine in the presence of ammonia was reddish brown, magnolia base colorless. UV (254μm) under berberine and palmatine has been reduced significantly bright yellow-green, magnolia minus was bright blue and purple, jatrorrhizine noticeable dark spots. 
Even first-class taste: more clustering of branching solid fat, between the bridge and not longer than 2cm. No less than 1.5cm broken section, residual stems, scorch, impurities, mildew. Second: First Article relatively thin, there is the bridge. Inter have broken section, slag, scorch. More than in the same and other goods. 
Chemical composition editor
Rhizome is a famous traditional Chinese medicine, "berberine" containing berberine, berberine, methyl coptisine, palm leaf tetradrine other alkaloids, can cure acute conjunctivitis, acute bacterial dysentery, acute gastroenteritis, vomiting, carbuncle boils ulcers embolism. 
Roots containing berberine (berberine) 5.56% ~ 7.25%, coptisine (coptisine), table berberine (epiberberine), berberrubine (berberrubine), palm leaves have anti-alkali (palmatine), palmatine (columbamine ), jatrorrhizine (jatrorrhizine), methyl coptisine (worenine), Magnolia minus (magnoflorine), ferulic acid (ferulic acid), Cork ketone (obakunone), Cork lactone (obakulactone). 
Berberine only contained in the "Shen Nong's Herbal Classic" as a top grade. "Compendium of Materia Medica" records: "The root Pente and yellow, hence the name." Since ancient times, namely that the Sichuan-based origin, for example, "doctors do not record", he said: "Huang Liansheng Wu and Yang Shujun mountains, February 8 Mining month. "And Yang and Wu Shujun refer Sichuan. In addition, in the east of the Yangtze River as well as herbal record Hunan, Anhui provinces also produced, such as Tang Materia Medica records: "Quiet Night's thick, very strong bitter taste, treatment for the most thirsty, Koto (now the Yangtze River to the east) by section as Pente, Spa dysentery big with, today Cheng State (now Hunan Lixian) were surpassed. "Referring again rebuilt by the history of governance Syndrome spare herbal medicine," Li Zhou berberine "and" Xuanzhou (now Xuancheng) berberine "and" plant name, map test "in the berberine drawings, and particularly the latter two can be clearly identified namely the Department of Coptis (Coptis) plant doubt. It can be assumed in our country since ancient times Sichuan area of berberine C. chinensis and short calyx downstream along the Yangtze River Basin berberine C. chinensis var. Brevisepala simultaneously be medicinal. 
Plant Culture Editor
According to legend, a long time ago, Shizhu yellow old mountain dam in a village, there lived a surname Dr. Tao De. His wife gave birth to two male and two female. One year in case of natural disaster, his wife and two sons died one after another, because of a poor family, unable to raise three daughters gave of someone's home, leaving only the youngest daughter, father and daughter had each other. Dr. Tao hired a journeyman named berberine, for his flowers and herbs. Berberine good-hearted, hard-working and honest.
Before long, yellow dams along the old mountain many people have had a similar disease, mostly in patients with high fever irritability, chest tightness, vomiting, diarrhea, scabies disease, pain, and gradually one by one able-bodied people have lost the ability to work. Tao sensible youngest daughter, considered lucky, she did not pick up this strange disease, but also within its power to do some housework.
One spring, pottery youngest daughter outing to go out on the slopes, she suddenly found the edge of a leaf weeds have needle-like serrated, having a lot of cymes, yellow, green, or yellow-green, very nice , and easily pull these weeds, at first glance the shape of lotus roots festival beads, or like chicken feet, or like a curved rod bridge, she excitedly Strip home and plant in the garden.
Berberine on each watering to fertilizer plants, did not forget to give it a weed. Over time, weeds grow more lush, verdant Dicui.
Next summer, Dr. Tao out treatment, days did not go home, meantime, Tao youngest daughter is also confined to bed, do not drink anorexia, lean down day by day, only too skinny. Dr. Tao several fellow friends took pains to find ways, there is no cure Tao youngest woman disease.
Berberine thought, pottery girl open yellow-green flowers in the yard garden weed species, how not to give it a try? So that he will weed uprooted, washed, leaves pot with roots shall, cook a little while, he opened the lid and saw the pot of soup all boiled grass and the yellow.
Then pick up the spoon fetched a bowl berberine, youngest daughter was going to be sent, and suddenly thought, if toxic, would not harm the pottery girl? As their own to taste it, as long as they have not been poisoned, let Tao girl drink this soup. He then drained, but it tasted bitter.
After a two hour, berberine see he still alive, hands and feet are moving too, words were, ears to hear, and perceived, side letters that toxic weeds, this end of the bowl to make pottery youngest daughter dose, strange to say, Tao youngest daughter drink this soup weeds, disease actually like, she berberine said: "This is good medicine blindly, that is bitter." At this point, the youngest daughter of Tao crush a long time to say sorry for berberine hear : "I'm waiting for a man child, did not wait until, perhaps, and my life as bitter it!"
Atlas Atlas more
Entry pictures (4)
Berberine pictures (21)
Berberine whole plant
Berberine whole plant (2)
Berberine foliage (1)
Berberine fruit (1)
Berberine ▪ ▪ ▪ deltoidea Emei Coptis
▪ Five Leaves five-lobed berberine berberine ▪ ▪ teeta
Above species are distributed in China
Pharmacy · Related Tech Terms
Medicinal herbs ▪ ▪ ▪ ▪ fresh authentic ingredients medicine ▪ natural medicine
▪ ▪ collect and harvest production processing ▪ ▪ ▪ wither period of germination
▪ Storage ▪ drying ▪ dry season ▪ ▪ drying
Moth mildew ▪ ▪ ▪ ▪ swap ▪ weeping original plant identification
▪ original animal identification ▪ original mineral identification based source identification ▪ ▪ ▪ rhizome root
Leaves skin ▪ ▪ ▪ ▪ Fruit ▪ flower seeds
Characters Description whole plant ▪ ▪ ▪ ▪ ▪ the size of the surface characteristics of shape
Color and texture ▪ ▪ ▪ ▪ section fracture surface features ▪ chrysanthemum heart
1. berberine. Flora of China [reference date 2013-12-4]
2. berberine. China Medical Network [reference date 2013-12-4]
3. berberine. China Medical Network [reference date 2013-12-4]